Current Issue : April - June Volume : 2017 Issue Number : 2 Articles : 6 Articles
The present investigation was carried out to determine the nutritional and functional properties of T. cucumerina.Water extracts of\nfreeze dried flowers, fruits, and leaves of T. cucumerinawere evaluated for their total phenolic content (TPC), total flavonoid content\n(TFC), antioxidant activity, ...
There is a need for innovation in plant-derived pharmaceuticals, food supplements\nand nutraceutical products regarding the use of more eco-sustainable solvents for their extraction.\nFurthermore, the poor oral bioavailability of several phytochemicals with health promoting effects\nstimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents\n(NADES) are formed by natural compounds, and can be considered as future solvents being\nespecially useful for the preparation of nutraceuticals and food-grade extracts. In this paper\nvarious NADES were prepared using sugars, aminoacids and organic acids. Rutin (quercetin-3-O-\nÃ?±-L-rhamnopyranosyl-(1ââ? â??6))-Ã?²-D-glucopyranose) was used as a model compound to study\nNADES. Moreover, the effect of various eutectic mixtures on rutinââ?¬â?¢s water solubility was studied.\nProline/glutamic acid (2:1) and proline/choline chloride (1:1) mixtures have a solubility comparable\nto ethanol. The proline/glutamic acid (2:1) eutectic containing rutin was used in a pharmacokinetic\nstudy in Balb/c mice while bioavailability was compared to oral dosing of water suspension.\nPlasmatic levels of rutin were measured by HPLC-MS/MS showing increased levels and longer\nperiod of rutin permanence in plasma of NADES treated animals. This paper reports the possible use\nof non-toxic NADES for pharmaceutical and nutraceutical preparations....
Nutraceuticals are dietary compounds which have a role in the balance of anabolic\nand catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism\nnutraceuticals is increasingly considered for the management and, above all, the prevention\nof osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium\ninflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial\ndisease and, due to the great percentage of people suffering from it and the general increase in life\nexpectancy, OA is considered as one of the most significant causes of disability in the world. OA\nimpairs the structural integrity of articular cartilage that greatly depends on a balance between\nthe anabolic and catabolic processes which occur in chondrocytes and synovial fluid of the joints,\ntherefore the integration with nutraceutical compounds in diet increases the treatment options for\npatients with established OA beyond traditional rehabilitation, medications, and surgical strategies.\nIn our review, with respect to the current literature, we highlight some of many existing nutraceutical\ncompounds that could be used as integrators in a daily diet thanks to their easy availability, such as\nin olive oil, fish oil, and botanical extracts used as non-pharmacologic treatment....
Marine cone snails are potential organisms as a great source for deriving the non-nutritive pharmacologically active\nchemicals. In this study, the secondary metabolites of crude aqueous extract from the both venom gland and body tissue of\nmarine gastropod, Conus betulinus were investigated, employing the preliminary biochemical tests which included iodine,\nwagner, sodium hydroxide, sulfuric acid, keller-kiliani, concentrated sulfuric acid, molisch, benedict, barfoed, salkowski,\nninhydrin, biuret, millon, xanthoproteic, froth, lignin, sulphate, oxalic acid and malic acid. The results showed that alkaloids,\nlignins, saponins, saponin glycosides and inorganic acid were present in the extract of venom gland, as well as, phenolic\ncompounds, quninones and coumarins were found in the body tissue. Besides, lignin, proteins, organic acids, fixed oils and fat\nwere commonly observed in the both venom gland and body tissue extract. However, other secondary metabolites such as,\nflavonoids, glycosides, tannins, anthocyanins, betacyanins, flavanones, anthocynidins, phenolic flavonoids, phlobatannins,\nleucoanthocyanins, flavones, lactones, cellulose, gums and mucilage were absent in the both crude extract. Over all, these data\nsuggested that the venom gland and body tissue of this study animal could be a significant resource for the exploration of\nsecondary metabolites using the solvent extraction and employed in the beneficial effects on human cardio vascular system....
The present study focuses on determining the proximate composition of 26 brachyuran crabs which includes 13\nedible and 13 potentially useful crabs for edible purposes. Maximum percentage of protein content (on dry weight basis) was\nrecorded in Scylla serrata (76.03�±0.1 %) and minimum in Charybdis lucifera (66.53�±0.4%), maximum lipid was recorded in\nScylla olivacea (5.65�±0.03%) and minimum in Podopthalmus vigil (3.09�±0.5%), maximum carbohydrate content was recorded in\nCharybdis feriata (1.89�±0.1%) and minimum in Charybdis lucifera (0.41�±0.5%), maximum moisture content was recorded in\nScylla serrata (82.63�±0.3%) and minimum in Charybdis natator (76.23�±0.5%), maximum dry weight was recorded in Charybdis\nnatator (23.77�±0.06%) and minimum in Scylla serrata (17.37�±0.4%) and maximum ash content was recorded in Scylla olivacea\n(12.95�±0.3%) and minimum in Galene bispinosa (10.40�±0.3%). Among the crabs which are not used for edible purposes now,\nmaximum protein content was recorded in Neosarmatium asiaticum (72.97�±0.02%) and minimum in Macropthalmus depressus\n(62.23�±0.3%), maximum lipid in Neosarmatium asiaticum (7.81�±0.05%) and minimum in Macropthalmus depressus\n(4.00�±0.6%), maximum carbohydrate content in Cardisoma carnifex (1.96�±0.02%) and minimum in Uca lactea (0.55�±0.2%),\nmaximum moisture content in Neosarmatium asiaticum (81.62�±0.1%) and minimum in Uca lactea (77.12�±0.1%), maximum dry\nweight in Metopograpsus frontalis (22.38�±0.05%) and minimum in Neosarmatium asiaticum (18.38�±0.0%) and maximum ash in\nCardisoma carnifex (12.91�±0.3%) and minimum in Uca lactea (9.01�±0.0%). It is evident from the present study that crabs which\nare not used for edible purposes now also have good nutritive values and can be used for edible purposes....
Atherosclerosis is characterized by endothelial dysfunction, mainly induced by inflammation and oxidative stress. Increased\nreactive oxygen species (ROS) production together with increased adhesion molecules and thrombogenic tissue factor (TF)\nexpression on endothelial cells has a key role in proatherogenic mechanisms. Therefore downmodulation of these molecules could\nbe useful for reducing the severity of inflammation and atherosclerosis progression. Dehydrozingerone (DHZ) is a nutraceutical\ncompound with anti-inflammatory and antioxidant activities. In this studywe evaluated the ability ofDHZ and its symmetric dimer\nto modulate hydrogen peroxide- (H2O2-) induced ROS production in human umbilical vein endothelial cells (HUVEC). We also\nevaluated intercellular adhesionmolecule- (ICAM-) 1, vascular cell adhesionmolecule- (VCAM-) 1, and TF expression in HUVEC\nactivated by tumor necrosis factor- (TNF-) ...
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